An adventure is no fun if its too easy!--Sonic the HedgeHog
If you have been stopping in at data & donuts over the years it isn't a big secret that I enjoy listening to podcasts. Really informative and eclectic conversations like Two Scientists Walk Into a Bar featuring Jane Grogan, Principal Scientist of Cancer Immunology at Genentech.
The format of the podcast features a disembodied voice (the producer) asking some of the lay person questions as the scientists focus on conversations around human biology and often cancer immunology and tumor micro-environments.
Oncogenes are an interesting area of study. They are basically genes that have potential role in specific cells but can also initiate cancer pathways when mutated.
Now that we have identified a wide array of oncogenes you may be curious--why is it so hard to directly drug tumor cells? In the same way that tumor cells respond and direct their own environments (stromal infiltration for example) they also respond to their drug environments and develop resistance.
You may also be surprised to learn that only a few of the known oncogenes are indeed "druggable". For example what if the mutation means that the gene is missing? You need to understand the signaling pathway downstream to know how to target.
The sonic hedgehog pathway is important for development of every organ in the body. What happens to developmental pathways if mutations are activated?
You can read a little more about the pathway below:
A dual mechanism of activation of the Sonic Hedgehog pathway in anaplastic thyroid cancer: crosstalk with RAS-BRAF-MEK pathway and ligand secretion by tumor stroma
Join me for a free webinar on March 29th at 1:00 PM EST.
The 5 second rule: how dirty is your data?